Protective effect of vitamin c against nephrotoxicity in dichlorvos induced male albino rats

February 2022 | JRMMS

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Published: 17 February 2022


In the recent decades, we have witnessed the continuous increase in the use of pesticides such Dichlorvos worldwide which is due to the rapid growth in food production and the attempt in controlling vector-borne diseases as this has in turn led to the harmful effect on the environment and humanity. There is little knowledge surrounding the effect of this compound on the kidney and how protective measures like the administration of vitamin C can be used to curb its harmful side effect such as oxidative stress. Hence, this study was undertaken to analyze the toxicological effect of inhalation of DDVP (Sniper) on the kidney oxidative stress parameters of wistar rats and check whether Vitamin C (ascorbic acid) could possibly ameliorate the toxic effect. The research design is experimental which intends to investigate the ameliorative effects of ascorbic acid (vitamin C) on dichlorvos-induced toxicity on the liver of albino wistar rats. For the purpose of achieving this, an ethical clearance was applied for and obtained from the Research Ethics Committee of the University of Port Harcourt. Forty (40) albino male wistar rats were recruited for this research and were randomly placed into eight (8) groups of five (5) rats per group. A box-like cage measuring 40cm x 40cm x 15cm (6 in number) that was made of Perplex glass was used as inhalation chambers for the experimental rats for groups 3 – 8, data analysis done using SPSS version 25. On administration with 40ml DDVP/60ml distilled water of dichlorvos solution via inhalation for 28 days, there was degeneration of renal corpuscles (as marked by stars) which suggests necrosis. As a result of this necrotic event, there are marked signs of cyst-like dilated lumens (arrows) (Figure 4c). There were observable signs of normal kidney tissue architecture and arrangement, the renal corpuscle (RC) and the cortical labyrinth (CL) of this tissue were clearly seen (Figure 4d). The study clearly showed that vitamin C had a protective effect against the nephrotoxicity induced by this compounds (DDVP) on the rats.


Protective effect, Vitamin C, Nephrotoxicity, Dichlorvos, and Male Rats.

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